Bcl-2 Monoclonal Antibody (8E12)

protease binding protein binding channel activity channel inhibitor activity protein phosphatase binding ubiquitin protein ligase binding identical protein binding sequence-specific DNA binding protein heterodimerization activity BH3 domain binding protein phosphatase 2A binding binding, bridging DNA-binding transcription factor binding macromolecular complex binding BH domain binding

protein polyubiquitination release of cytochrome c from mitochondria apoptotic process humoral immune response cellular response to DNA damage stimulus female pregnancy positive regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to radiation response to xenobiotic stimulus response to toxic substance response to iron ion regulation of autophagy negative regulation of autophagy programmed cell death positive regulation of cell growth positive regulation of B cell proliferation hair follicle morphogenesis endoplasmic reticulum calcium ion homeostasis response to cytokine response to nicotine B cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process pigmentation regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of viral genome replication regulation of mitochondrial membrane permeability B cell receptor signaling pathway neuron apoptotic process defense response to virus regulation of mitochondrial membrane potential negative regulation of mitochondrial depolarization regulation of calcium ion transport transmembrane transport intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of intracellular signal transduction negative regulation of anoikis regulation of apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway cell morphogenesis ossification ovarian follicle development metanephros development ureteric bud development branching involved in ureteric bud morphogenesis behavioral fear response leukocyte homeostasis B cell homeostasis kidney development regulation of cell-matrix adhesion lymphocyte homeostasis lymphoid progenitor cell differentiation B cell lineage commitment T cell lineage commitment immune system development response to ischemia renal system process protein dephosphorylation melanin metabolic process regulation of nitrogen utilization cellular calcium ion homeostasis response to oxidative stress actin filament organization axonogenesis cell proliferation negative regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic mitochondrial changes post-embryonic development organ morphogenesis response to UV-B response to gamma radiation regulation of gene expression negative regulation of calcium ion transport into cytosol regulation of glycoprotein biosynthetic process negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development positive regulation of neuron maturation positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cochlear nucleus development gland morphogenesis hemopoiesis B cell differentiation T cell differentiation negative regulation of ossification negative regulation of cell growth melanocyte differentiation negative regulation of cell migration axon regeneration regulation of protein stability glomerulus development regulation of protein localization negative regulation of myeloid cell apoptotic process T cell differentiation in thymus positive regulation of peptidyl-serine phosphorylation negative regulation of osteoblast proliferation organ growth regulation of growth positive regulation of multicellular organism growth cellular response to glucose starvation response to hydrogen peroxide T cell homeostasis regulation of programmed cell death positive regulation of catalytic activity CD8-positive, alpha-beta T cell lineage commitment ear development response to ethanol positive regulation of melanocyte differentiation negative regulation of mitotic cell cycle negative regulation of retinal cell programmed cell death focal adhesion assembly developmental pigmentation regulation of developmental pigmentation positive regulation of developmental pigmentation spleen development thymus development response to steroid hormone digestive tract morphogenesis developmental growth oocyte development positive regulation of skeletal muscle fiber development pigment granule organization homeostasis of number of cells within a tissue regulation of catalytic activity response to glucocorticoid regulation of cell cycle cellular response to hypoxia reactive oxygen species metabolic process cell-cell adhesion negative regulation of G1/S transition of mitotic cell cycle