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BCL-2 Antibodies

Antibodies that detect BCL-2 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and SDS-PAGE. These antibodies target BCL-2 in Human, Mouse, Rat, Bovine and Rabbit samples. Our BCL-2 monoclonal, polyclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Mouse, Rabbit, Sheep and Goat. These antibodies have been verified by Knockout, Relative expression, Cell treatment and Knockdown to confirm specificity to BCL-2. Find the BCL-2 antibody that fits your needs. Choose from 1 of 169 BCL-2 antibodies, which have been validated in experiments with 308 publications and 663 images ... View more Antibodies that detect BCL-2 can be used in several scientific applications, including Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry and SDS-PAGE. These antibodies target BCL-2 in Human, Mouse, Rat, Bovine and Rabbit samples. Our BCL-2 monoclonal, polyclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Mouse, Rabbit, Sheep and Goat. These antibodies have been verified by Knockout, Relative expression, Cell treatment and Knockdown to confirm specificity to BCL-2. Find the BCL-2 antibody that fits your needs. Choose from 1 of 169 BCL-2 antibodies, which have been validated in experiments with 308 publications and 663 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.

Synonyms

apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50

Target Video

6320248661112

BCL-2 antibodies from Thermo Fisher Scientific

https://cf-images.us-east-1.prod.boltdns.net/v1/static/3663210762001/4a04ca41-3153-4445-bbd6-54eb3b303b85/36d5abee-a05d-4ca1-bc05-c517a9cc6f47/320x180/match/image.jpg

Learn more about BCL-2 primary antibodies that can be used in Immunohistochemistry, Western Blot, Flow Cytometry and Immunocytochemistry in Human, Mouse, Rat and Bovine samples.

bcl-2

PT0M37S

2023-02-12T10:55:35.775Z

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