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Invitrogen
Klotho Monoclonal Antibody (C3)
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Product Details
MA5-43726
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
C3
Immunogen
Phe765-Ser981 (Accession Q9UEF7), with Two N-terminal Tags, His-tag and SUMO-tag
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-klotho; beta-glucuronidase; HFTC3; klotho; unnamed protein product
Gene Aliases: HFTC3; KLA
UniProt ID: (Human) Q9UEF7
Entrez Gene ID: (Human) 9365
negative regulation of systemic arterial blood pressure
carbohydrate metabolic process
fibroblast growth factor receptor signaling pathway
response to activity
positive regulation of bone mineralization
response to vitamin D
norepinephrine biosynthetic process
response to fibroblast growth factor
response to angiotensin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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