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Invitrogen

HSP70/HSC70 Monoclonal Antibody (BB70), APC

View all (8) HSP70/HSC70 antibodies

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Product Details

MA5-45099

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:2,000
-

Immunocytochemistry (ICC/IF)

1:200
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Fruit fly, Fish, Guinea pig, Hamster, Human, Mammal, Mouse, Sheep, Pig, Rabbit, Rat, Xenopus, Yeast

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

BB70

Immunogen

Chicken HSP70/HSP90 complex

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

95.64mM phosphate/2.48mM MES, pH 7.2, with 0.5M EDTA

Contains

no preservative

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931553

Product Specific Information

1 µg/mL of MA5-45099 was sufficient for detection of HSP70 and HSC70 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 72 (HSP) and approximately 73kDa (HSC).

Target Information

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Chagas Disease and Babesiosis. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Cellular responses to stimuli. An important paralog of this gene is HSPH1. HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include Auditory System Disease and Borna Disease. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Selective autophagy. Gene Ontology (GO) annotations related to this gene include RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 5a; epididymis secretory sperm binding protein Li 72p; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 4; Heat shock 70 kDa protein 8; Heat shock 70-related protein APG-2; heat shock 70kd protein 10; heat shock 70kd protein 10 (HSC71); heat shock 70kD protein 4; heat shock 70kD protein 8; heat shock 70kDa protein 1-like; heat shock 70kDa protein 4; heat shock 70kDa protein 8; heat shock cognate 70; heat shock cognate 71 kD protein; Heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 8; heat shock protein A8; heat shock protein Apg-2; heat shock protein cognate 70; Heat shock protein family A member 8; Heat shock protein family H member 2; heat shock protein, 110 kDa; Hsc70 ATPase; hsp70 RY; HSP70RY; HSPA4/HSPA8; Ischemia responsive 94 kDa protein; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; unnamed protein product

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Gene Aliases: 2410008N15Rik; 70kDa; AI317151; APG-2; APG2; HEL-33; HEL-S-5a; HEL-S-72p; HS24/P52; HSC54; HSC70; hsc70.I; HSC71; Hsc73; Hsp110; HSP70; Hsp70RY; HSP71; HSP73; HSPA1; HSPA10; hspa1l; HSPA4; HSPA8; HSPH2; I79_004332; I79_022974; Irp94; LAP-1; LAP1; mKIAA4025; NIP71; RY; XELAEV_18037286mg; xhsp70

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UniProt ID: (Dog) Q7YQC6, (Dog) Q2TFN9, (Human) P34932, (Human) P11142, (Chicken) O73885, (Bovine) P19120, (Rat) O88600, (Rat) P63018, (Mouse) P63017, (Chinese hamster) P19378

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Entrez Gene ID: (Dog) 403612, (Chicken) 416339, (Dog) 474680, (Sheep) 101122782, (Pig) 100524853, (Bovine) 536558, (Human) 3308, (Rabbit) 100338049, (Dog) 479406, (Sheep) 101112844, (Human) 3312, (Chicken) 395853, (Bovine) 281831, (Rabbit) 100348873, (Pig) 100511890, (Mouse) 15525, (Rat) 266759, (Guinea pig) 100735343, (Chinese hamster) 100764628, (Guinea pig) 100713849, (Rat) 24468, (Mouse) 15481, (Chinese hamster) 100689472, (Western clawed frog) 100037899, (Xenopus) 379760

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Function(s)
protein binding ATP binding nucleotide binding adenyl-nucleotide exchange factor activity ATP-dependent protein folding chaperone G-protein coupled receptor binding RNA binding hydrolase activity ATPase activity enzyme binding MHC class II protein complex binding protein binding, bridging heat shock protein binding ubiquitin protein ligase binding protein binding involved in protein folding cadherin binding receptor agonist activity unfolded protein binding chaperone binding C3HC4-type RING finger domain binding ATP-dependent protein disaggregase activity misfolded protein binding clathrin-uncoating ATPase activity RNA polymerase II transcription factor binding protein complex binding activating transcription factor binding receptor binding ATPase activity, coupled ADP binding poly(A) RNA binding
Process(es)
negative regulation of protein phosphorylation response to heat positive regulation of gene expression negative regulation of gene expression positive regulation of protein binding negative regulation of apoptotic process negative regulation of DNA binding protein import into mitochondrial outer membrane chaperone-mediated protein complex assembly negative regulation of cell death kidney development positive regulation of angiogenesis transcription, DNA-templated mRNA processing protein folding RNA splicing protein refolding negative regulation of transcription, DNA-templated positive regulation of mRNA splicing, via spliceosome chaperone mediated protein folding requiring cofactor regulation of cell cycle chaperone-mediated protein folding clathrin coat disassembly negative regulation of fibril organization mRNA splicing, via spliceosome autophagy response to unfolded protein signal transduction cellular response to starvation negative regulation of signal transduction protein catabolic process positive regulation of cell migration regulation of protein stability cellular response to stress regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of protein complex assembly ATP metabolic process negative regulation of cellular component organization membrane organization regulation of protein complex stability chaperone-mediated autophagy protein targeting to lysosome involved in chaperone-mediated autophagy cellular response to steroid hormone stimulus negative regulation of NLRP3 inflammasome complex assembly regulation of fibril organization regulation of protein import chaperone-mediated autophagy translocation complex disassembly regulation of transcription, DNA-templated gastrulation axo-dendritic transport embryo development ending in birth or egg hatching vesicle-mediated transport cellular response to unfolded protein embryonic organ development late endosomal microautophagy chaperone-mediated protein transport involved in chaperone-mediated autophagy slow axonal transport synaptic vesicle uncoating protein import into mitochondrial matrix positive regulation of microtubule nucleation regulation of mitotic spindle assembly
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