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Invitrogen
MAP2 Monoclonal Antibody (2C4)
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FIGURE: 1 / 9
MAP2 Antibody (MA5-47302) in IHC (P)
Immunohistochemical analysis of MAP2 was performed using formalin-fixed paraffin-embedded mouse brain and mouse skeletal muscle tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Cel... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-47302
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2C4
Immunogen
Full length recombinant human MAP2D protein expressed in and purified from E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MAP2A/B ~280 kDa, MAP2C/D ~70 kDa by SDS-PAGE
Target Information
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC091465.1; DKFZp686I2148; MAP 2; map-2a; map2ab; microtubule associated protein 2; microtubule-associated protein 2C; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
Gene Aliases: G1-397-34; MAP-2; MAP2A; MAP2B; MAP2C; MAP2R; Mtap-2; Mtap2; repro4
UniProt ID: (Human) P11137, (Mouse) P20357, (Rat) P15146
Entrez Gene ID: (Human) 4133, (Mouse) 17756, (Rat) 25595
microtubule cytoskeleton organization
microtubule bundle formation
negative regulation of microtubule depolymerization
axonogenesis
dendrite development
central nervous system neuron development
establishment of cell polarity
negative regulation of axon extension
negative regulation of microtubule polymerization
neuron projection development
regulation of protein localization
dendrite morphogenesis
regulation of microtubule-based movement
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
regulation of neurofibrillary tangle assembly
positive regulation of anterograde synaptic vesicle transport
response to estradiol
response to progesterone
regulation of microtubule polymerization
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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