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Invitrogen
Cytokeratin Pan Polyclonal Antibody
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Product Details
PA1-27114
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cytokeratin isolated from bovine muzzle epidermis.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
IgG fraction
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody will detect Cytokeratins 4, 5, 6, (and to a lesser extent) 8, 14, and 16.
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 39.1; 40-kDa keratin intermediate filament; 58 kDa cytokeratin; 65 kDa cytokeratin; 67 kDa cytokeratin; Cell proliferation-inducing gene 46 protein; CK-1; CK-10; CK-13; CK-14; CK-15; CK-16; CK-17; CK-18; CK-19; CK-1B; CK-2e; CK-2P; CK-3; CK-4; CK-5; CK-6A; CK-6D; CK-7; CK-8; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 2; cytokeratin 3; cytokeratin 4; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7; cytokeratin 8; cytokeratin type II, component Ia; cytokeratin type II, component Ib/c; cytokeratin type II, component III; Cytokeratin VIB; cytokeratin VII; Cytokeratin-1; Cytokeratin-10; Cytokeratin-13; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-17; Cytokeratin-18; Cytokeratin-19; Cytokeratin-1B; Cytokeratin-2e; Cytokeratin-2P; Cytokeratin-3; Cytokeratin-4; Cytokeratin-5; Cytokeratin-6A; Cytokeratin-6B; Cytokeratin-6D; Cytokeratin-7; Cytokeratin-8; Cytokeratin-A; cytoskeletal protein; epidermal keratin VII; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; epidermolytic hyperkeratosis 1; epidermolytic hyperkeratosis; keratosis palmaris et plantaris; Epithelial keratin-2e; focal non-epidermolytic palmoplantar keratoderma; Hair alpha protein; HLA-DRB1-restricted epitope S1; HLA-DRB1-restricted epitope S2; HLA-DRB1-restricted epitope S3; HLA-DRB1-restricted epitope S4; HMWCK; intermediate filament protein K16; intermediate filament protein; K7; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K2e; K2P; K3; K4; K5; K6A; K7; K76; K77; K8; KERA; keratin 1, type II; keratin 10 (epidermolytic hyperkeratosis); keratin 10, type I; keratin 13, type I; keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 17, type I; keratin 18, type I; keratin 19, type I; Keratin 1B; keratin 2, type II; keratin 2p; keratin 3, type II; keratin 4, type II; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 6 alpha; keratin 6A, , type II; keratin 6A, type II; keratin 7, type II; keratin 76, type II; keratin 77, type II; keratin 8, type II; keratin IV; keratin K5; keratin type II; Keratin type II cytoskeletal 5; keratin, 55K type II cytoskeletal; keratin, epidermal type II, K6A; keratin, simple epithelial type I, K7; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; keratin, type I, 40-kd; Keratin, type II cytoskeletal 1; Keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 2 epidermal; Keratin, type II cytoskeletal 2 oral; Keratin, type II cytoskeletal 3; Keratin, type II cytoskeletal 4; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 6A; Keratin, type II cytoskeletal 7; Keratin, type II cytoskeletal 8; Keratin-1; Keratin-10; Keratin-13; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-17; Keratin-18; Keratin-19; Keratin-2 epidermis; Keratin-2e; Keratin-3; Keratin-4; Keratin-5; Keratin-6A; Keratin-7; Keratin-76; Keratin-77; Keratin-8; KRT1B; KRT5; ORF; Pan CK; pan Cytokeratin; pan keratin; pankeratin; PIG46; Sarcolectin; type I cytoskeletal 15; type II cytokeratin A (no.8); type II cytoskeletal 1b; type II keratin subunit protein; type II mesothelial keratin K7; Type-II keratin Kb1; Type-II keratin Kb2; Type-II keratin Kb3; Type-II Keratin Kb39; Type-II keratin Kb4; Type-II keratin Kb5; Type-II keratin Kb6; Type-II keratin Kb7; Type-II keratin Kb8; Type-II keratin Kb9; unnamed protein product
Gene Aliases: 39.1; AEI2; BCIE; BIE; CARD2; CK-17; CK-18; CK-2e; CK-4; CK-6C; CK-6E; CK-8; CK1; CK10; CK13; CK14; CK15; CK16; CK19; CK3; CK4; CK5; CK6A; CK6C; CK6D; CK7; CK8; CYK18; CYK4; CYK8; DDD; DDD1; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EBS3; EBS4; EHK; EHK1; EHK2; EHK2A; EHK2B; EPPK; FNEPPK; HUMCYT2A; IHL; K1; K10; K13; K14; K15; K16; K17; K18; K19; K1B; K1CO; K1CP; K1CS; K2C7; K2C8; K2e; K3; K4; K5; K6A; K6C; K6D; K7; K8; KERIA; KERIB; KO; KPP; KRT1; KRT10; KRT13; KRT14; KRT15; KRT16; KRT16A; KRT17; KRT18; KRT19; KRT1A; KRT1B; KRT2; KRT2-8; KRT2A; KRT2B; KRT2E; KRT2P; KRT3; KRT4; KRT5; KRT5A; KRT6A; KRT6C; KRT6D; KRT7; KRT76; KRT77; KRT8; KRTA; KRTB; KRTE; MECD2; NEPPK; NFJ; PC; PC1; PC2; PC3; PCHC1; PIG46; SCL; WSN1; WSN2
UniProt ID: (Human) P04264, (Bovine) P06394, (Human) P13645, (Human) P13646, (Human) P02533, (Human) P19012, (Human) P08779, (Human) Q04695, (Bovine) A1L595, (Human) P05783, (Bovine) P08728, (Human) P08727, (Human) P35908, (Human) P12035, (Human) P19013, (Bovine) Q5XQN5, (Human) P13647, (Human) P02538, (Human) P08729, (Bovine) Q29S21, (Human) Q01546, (Human) Q7Z794, (Bovine) P05786, (Human) P05787
Entrez Gene ID: (Human) 3848, (Bovine) 281888, (Human) 3858, (Human) 3860, (Human) 3861, (Bovine) 404111, (Bovine) 507464, (Human) 3866, (Human) 3868, (Human) 3872, (Bovine) 281889, (Bovine) 506480, (Human) 3875, (Bovine) 514812, (Human) 3880, (Human) 3849, (Bovine) 407188, (Human) 3850, (Human) 3851, (Bovine) 527819, (Bovine) 281268, (Human) 3852, (Bovine) 614456, (Human) 3853, (Human) 3855, (Bovine) 535697, (Human) 51350, (Bovine) 407189, (Human) 374454, (Bovine) 281269, (Human) 3856
protein binding
carbohydrate binding
structural constituent of epidermis
signaling receptor activity
protein heterodimerization activity
structural molecule activity
structural constituent of cytoskeleton
keratin filament binding
scaffold protein binding
RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
macromolecular complex binding
cytoskeletal protein binding
morphogenesis of an epithelium
cytoskeleton organization
epithelial cell differentiation
regulation of translation in response to stress
intermediate filament organization
Notch signaling pathway
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
positive regulation of cell growth
hair follicle morphogenesis
keratinization
positive regulation of translation
positive regulation of hair follicle development
positive regulation of epidermis development
protein heterotetramerization
negative regulation of epithelial cell proliferation
inflammatory response
keratinocyte differentiation
negative regulation of cell migration
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
peptide cross-linking
epidermis development
response to radiation
intermediate filament bundle assembly
stem cell differentiation
positive regulation of cell proliferation
cell differentiation
killing of cells of other organism
wound healing
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of entry of bacterium into host cell
response to mechanical stimulus
regulation of cell migration
regulation of protein localization
intermediate filament polymerization
anatomical structure morphogenesis
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell-cell adhesion
response to other organism
pigmentation
sebaceous gland development
complement activation, lectin pathway
response to oxidative stress
fibrinolysis
regulation of angiogenesis
negative regulation of inflammatory response
keratinocyte development
keratinocyte activation
keratinocyte proliferation
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