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Invitrogen
ING4 Polyclonal Antibody
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Product Details
PA5-111452
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein fragment of Human ING4 (Product #RP-95605).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EKQIESSDYD SSSSKGKKKG RTQKEKKAAR ARSKGKNSDE EAPKTAQKKL KLVRTSPEYG MPSVTFGSVH
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 93%.
Target Information
The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain my036 protein; candidate tumor suppressor p33 ING1 homolog; Inhibitor of growth protein 4; p29ING4; unnamed protein product
Gene Aliases: ING4; My036; p29ING4
UniProt ID: (Human) Q9UNL4
Entrez Gene ID: (Human) 51147
transcription coactivator activity
protein binding
zinc ion binding
histone acetyltransferase activity (H3-K14 specific)
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K12 specific)
metal ion binding
histone acetyltransferase activity (H4-K16 specific)
histone H3K4me3 reader activity
regulation of cell growth
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
protein acetylation
apoptotic process
negative regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
negative regulation of growth
regulation of cell cycle
DNA replication-dependent chromatin disassembly
regulation of cell cycle G2/M phase transition
regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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