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Invitrogen
PLA1 Polyclonal Antibody
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Product Details
PA5-139916
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human POU2F3. Recombinant protein control fragment (Product #RP-109346).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: PVHSTMPGTV TSSCSPGNNS RPSSPGSGLH ASSPTASQNN SKAAVNSASS FNSSGSWYRW NHSTYL
Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 90%.
Target Information
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11-Oct; FLJ40063; MGC126698; Oct-11; Octamer-binding protein 11; Octamer-binding transcription factor 11; OTF-11; POU domain transcription factor OCT11a; POU domain, class 2, transcription factor 3; Skn-1a, Epoc-1; Transcription factor PLA-1; Transcription factor Skn-1; unnamed protein product
Gene Aliases: Epoc-1; OCT-11; OCT11; OTF-11; OTF11; PLA-1; PLA1; POU2F3; Skn-1a
UniProt ID: (Human) Q9UKI9
Entrez Gene ID: (Human) 25833
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
epidermis development
cell differentiation
keratinocyte differentiation
wound healing
negative regulation by host of viral transcription
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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