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Invitrogen
Endothelin 3 Polyclonal Antibody
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Product Details
PA5-22303
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Endothelin 3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Amount
52 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelin 3 precursor; Endothelin-3; ET 3; ET-3; MGC15067; MGC61498; PPET3; Preproendothelin 3; Preproendothelin-3; RP4-614C15.1
Gene Aliases: EDN3; ET-3; ET3; HSCR4; PPET3; WS4B
UniProt ID: (Human) P14138
Entrez Gene ID: (Human) 1908
neural crest cell migration
positive regulation of leukocyte chemotaxis
regulation of systemic arterial blood pressure by endothelin
cellular calcium ion homeostasis
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
axon guidance
blood circulation
cell proliferation
positive regulation of cell proliferation
positive regulation of heart rate
regulation of gene expression
cellular magnesium ion homeostasis
artery smooth muscle contraction
vein smooth muscle contraction
regulation of vasoconstriction
peptide hormone secretion
neuron differentiation
melanocyte differentiation
regulation of cell migration
neutrophil chemotaxis
neuron projection development
vasoconstriction
positive regulation of MAPK cascade
positive regulation of cell differentiation
positive regulation of mitotic nuclear division
positive regulation of smooth muscle contraction
positive regulation of hormone secretion
regulation of developmental pigmentation
axon extension
establishment of localization in cell
potassium ion transmembrane transport
regulation of blood vessel diameter
positive regulation of potassium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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