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Invitrogen
KV4.3 (KCND3) Polyclonal Antibody
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Product Details
PA5-30942
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Kv4.3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Amount
88 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: IMR32, U87-MG.
Predicted reactivity: Mouse (98%), Rat (99%), Rabbit (97%), Chicken (89%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type voltage-gated potassium channel KCND3; long splice variant; potassium channel, voltage gated Shal related subfamily D, member 3; potassium ionic channel Kv4.3; potassium voltage-gated channel long; Potassium voltage-gated channel subfamily D member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; sha1-related potassium channel Kv4.3; shal-related family member 3; similar to cardiac ITO1; voltage-gated K+ channel; Voltage-gated potassium channel subunit Kv4.3
Gene Aliases: BRGDA9; KCND3; KCND3L; KCND3S; KSHIVB; KV4.3; SCA19; SCA22
UniProt ID: (Human) Q9UK17
Entrez Gene ID: (Human) 3752
ion channel activity
voltage-gated potassium channel activity
A-type (transient outward) potassium channel activity
potassium channel activity
protein binding
metal ion binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
action potential
ion transport
potassium ion transport
muscle contraction
chemical synaptic transmission
regulation of heart contraction
ion transmembrane transport
protein homooligomerization
protein tetramerization
transmembrane transport
potassium ion transmembrane transport
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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