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Invitrogen
ATP4A Polyclonal Antibody
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Product Details
PA5-58673
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP4A. Recombinant protein control fragment (Product #RP-95785).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TDYFTAMAQE GWFPLLCVGL RAQWEDHHLQ DLQDSYGQ
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
The ATP4A gene encodes the alpha subunit of the gastric H+/K+ ATPase, an enzyme crucial for gastric acid secretion in the stomach. This proton pump resides in the parietal cells of the gastric mucosa and is responsible for exchanging potassium ions (K+) for hydrogen ions (H+), effectively acidifying the stomach contents. ATP4A plays a significant role in maintaining the acidic environment necessary for digestion and defense against pathogens. The ATPase's activity is tightly regulated by various factors, including hormones like gastrin and histamine, to ensure optimal stomach function. Mutations in ATP4A can lead to disorders related to gastric acidity, such as hypochlorhydria (low stomach acid), which can impact digestion and absorption of nutrients. Understanding ATP4A's function and its regulatory mechanisms is essential for developing treatments for conditions like peptic ulcer disease and gastroesophageal reflux disease, where gastric acid secretion is disrupted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase H+/K+ transporting alpha subunit; ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; epididymis secretory sperm binding protein; Gastric H(+)/K(+) ATPase subunit alpha; gastric H+/K+ ATPase alpha subunit; gastric H,K-ATPase catalytic subunit; gastric hydrogen-potassium ATPase; Potassium-transporting ATPase alpha chain 1; Proton pump
Gene Aliases: ATP4A; ATP6A
UniProt ID: (Human) P20648
Entrez Gene ID: (Human) 495
ion transport
potassium ion transport
cellular sodium ion homeostasis
response to xenobiotic stimulus
regulation of proton transport
establishment or maintenance of transmembrane electrochemical gradient
cellular potassium ion homeostasis
ion transmembrane transport
sodium ion export from cell
pH reduction
potassium ion transmembrane transport
hydrogen ion transmembrane transport
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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