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Invitrogen
CCDC114 Polyclonal Antibody
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Product Details
PA5-60012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC114. Recombinant protein control fragment (Product #RP-98955).
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SKDDQHLLQE QQQKVLQQRM DKVHSEAERL EARFQDVRGQ LEKLKADIQL LFTKAHCDSS MIDDLLGVKT SMGDRDMGLF LSLIEKRLVE
Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 70%.
Target Information
The CCDC114 gene, located on chromosome 19, encodes a protein that is a key component of the structure and function of cilia, which are hair-like organelles present on the surface of many cell types. Structurally, CCDC114 belongs to the coiled-coil domain-containing family, which plays crucial roles in cellular organizations and motility. Functionally, CCDC114 is involved in forming the outer dynein arm of cilia, essential for their motility. Mutations in CCDC114 can lead to defects in ciliary structure, resulting in primary ciliary dyskinesia (PCD), a condition characterized by chronic respiratory tract infections, abnormal organ positioning, and other symptoms. Specifically, mutations like c.742G>A and c.584T>C have been identified to cause variant forms of PCD, as well as situs inversus, which is a complete mirror image reversal of the body's internal organ arrangement. Genetic investigations have shown that these mutations can significantly disrupt the function of cilia, confirming CCDC114's critical role in human ciliopathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 114; Coiled-coil domain-containing protein 114; Outer dynein arm-docking complex subunit 1; unnamed protein product
Gene Aliases: CCDC114; CILD20; ODAD1
UniProt ID: (Human) Q96M63
Entrez Gene ID: (Human) 93233
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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