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Invitrogen
TMEM119 Polyclonal Antibody
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Product Details
PA5-62661
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TM119. Recombinant protein control fragment (Product #RP-101538).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ITRQKQKASA YYPSSFPKKK YVDQSDRAGG PRAFSEVPDR APDSRPEEAL D
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
Target Information
Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment. Microglia are particularly mobile in areas of the brain undergoing restructuring. Reactive microglia co-express the marker Iba1. In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis. The specific function Tmem119 plays on microglial cells remains unclear. Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OBIF; Osteoblast induction factor; Transmembrane protein 119; unnamed protein product
Gene Aliases: OBIF; PSEC0199; TMEM119; UNQ731/PRO1415
UniProt ID: (Human) Q4V9L6
Entrez Gene ID: (Human) 338773
ossification
osteoblast differentiation
endochondral ossification
spermatogenesis
positive regulation of gene expression
negative regulation of myotube differentiation
cell differentiation
positive regulation of bone mineralization
BMP signaling pathway
biomineral tissue development
positive regulation of osteoblast proliferation
positive regulation of osteoblast differentiation
negative regulation of bone resorption
spermatid differentiation
positive regulation of bone development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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