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Invitrogen
ERO1L Polyclonal Antibody
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FIGURE: 1 / 9
ERO1L Antibody (PA5-82929) in IHC (P)
Immunohistochemistry analysis of ERO1L in human placenta, skeletal muscle, small intestine and squamous epithelia. Samples were incubated with ERO1L polyclonal antibody (Product # PA5-82929). Shows similar protein distribution across tissues to independent ERO1L antibody (Product # PA5-83121) (B).
Product Details
PA5-82929
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ERO1A. Recombinant protein control fragment (Product #RP-89563).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LLQETWLEKK WGHNITEFQQ RFDGILTEGE GPRRLKNLYF LYLIELRALS KVLPFFERPD FQLFTGNKIQ DEENKMLLLE ILHEIKSFPL HFDENSFFAG DKKEAHKLKE
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 94%.
Target Information
ERO1L (endoplasmic oxidoreductin-1-like protein) is localized in ER membrane as peripheral membrane protein on the lumenal side. Its association with ERP44 is essential for its retention in the ER and is unique in coupling oxygen reduction to de novo disulfides formation. The ERO1L enzyme is broadly distributed at low levels in several tissues with highest levels in the upper digestive tract and is stimulated by hypoxia via HIF-signaling. ERO1L generally exists as monomer, but has the ability to function as monomer or homodimer and interacts with PDILT. After translation, ERO1L gets n-glycosylated and the disulfide bonds constitute the redox-active center whereby the Cys-94/Cys-99 disulfide bond accepts an electron from P4HB followed by funneling the same to the active site disulfide Cys-394/Cys-397. ERO1L acts by oxidizing directly to P4HB/PDI isomerase through direct disulfide exchange and associates with ERP44. ERO1L is implicated in immunoglobulin folding, oxidative stress, release of unfolded cholera toxin from reduced P4HB/PDI upon Vibrio cholerae infection, and plays a key role in ER stress-induced CHOP-dependent apoptosis through inositol 1,4,5-trisphosphate receptor IP3R1 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Endoplasmic oxidoreductin-1-like protein; Endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; ero1; ERO1-L; ERO1-L-alpha; ERO1-like protein alpha; Global ischemia-induced protein 11; Oxidoreductin-1-L-alpha
Gene Aliases: ERO1-alpha; ERO1-L; ERO1-L-alpha; ERO1A; Ero1alpha; ERO1L; ERO1LA; Giig11; UNQ434/PRO865
UniProt ID: (Human) Q96HE7, (Rat) Q8R4A1
Entrez Gene ID: (Human) 30001, (Rat) 171562
response to reactive oxygen species
protein folding
cellular protein modification process
response to temperature stimulus
organ senescence
4-hydroxyproline metabolic process
protein maturation by protein folding
extracellular matrix organization
endoplasmic reticulum unfolded protein response
response to endoplasmic reticulum stress
cell redox homeostasis
brown fat cell differentiation
chaperone mediated protein folding requiring cofactor
release of sequestered calcium ion into cytosol
oxidation-reduction process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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