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Invitrogen
HIP55 Polyclonal Antibody
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FIGURE: 1 / 8
HIP55 Antibody (PA5-82988) in IHC (P)
Immunohistochemistry analysis of HIP55 in human cerebral cortex, liver, lymph node and testis. Samples were incubated with HIP55 polyclonal antibody (Product # PA5-82988). Shows similar protein distribution across tissues to independent HIP55 antibody (Product # PA5-82717) (B).
Product Details
PA5-82988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DBNL. Recombinant protein control fragment (Product #RP-92734).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPEQETFYEQ PPLVQQQGAG SEHIDHHIQG QGLSGQGLCA RALYDYQAAD DTEISFDPEN LITGIEVIDE GWWRGYGPDG H
Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 86%.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Abp1; Actin-binding protein 1; adaptor protein; Cervical mucin-associated protein; Cervical SH3P7; dbnl; dbnl {ECO:0000312|EMBL:AAH72483.1}; drebrin F; Drebrin-F; Drebrin-like protein; HIP-55; HPK1-interacting protein of 55 kDa; SH3 domain-containing protein 7; src homology 3 domain-containing protein HIP-55; unnamed protein product
Gene Aliases: ABP1; CMAP; DBNL; HIP-55; HIP55; mAbp1; PP5423; SH3P7
UniProt ID: (Human) Q9UJU6, (Rat) Q9JHL4, (Mouse) Q62418
Entrez Gene ID: (Human) 28988, (Rat) 83527, (Mouse) 13169
actin binding
protein binding
enzyme activator activity
protein domain specific binding
cadherin binding
actin filament binding
structural constituent of postsynaptic actin cytoskeleton
protein C-terminus binding
actin or actin-binding cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein
adaptive immune response
immune system process
endocytosis
synapse assembly
Rac protein signal transduction
neuron projection morphogenesis
membrane organization
podosome assembly
postsynaptic actin cytoskeleton organization
receptor-mediated endocytosis
actin filament severing
barbed-end actin filament capping
actin filament bundle assembly
ruffle assembly
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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