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Invitrogen
TMP21 Polyclonal Antibody
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FIGURE: 1 / 7
TMP21 Antibody (PA5-84012) in IHC (P)
Immunohistochemistry analysis of TMP21 in human duodenum, endometrium, salivary gland and skeletal muscle. Samples were incubated with TMP21 polyclonal antibody (Product # PA5-84012). Shows similar protein distribution across tissues to independent TMP21 antibody (Product # PA5-83857) (B).
Product Details
PA5-84012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TMED10. Recombinant protein control fragment (Product #RP-99885).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SFHLPINSRK CLREEIHKDL LVTGAYEISD QSGGAGGLRS HLKITDSAGH ILYSKEDATK GKFAFTTEDY D
Highest antigen sequence indentity to the following orthologs: Rat - 94%, Mouse - 94%.
Target Information
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p23; p24 family protein delta-1; p24delta; p24delta1; Protein TMED10; S31I125; S31III125; testicular tissue protein Li 206; Tmp-21-I; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; Transmembrane protein Tmp21
Gene Aliases: p23; P24(DELTA); p24d1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21
UniProt ID: (Human) P49755
Entrez Gene ID: (Human) 10972
kidney development
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
cargo loading into vesicle
COPI-coated vesicle budding
response to alkaloid
regulated exocytosis
vesicle targeting, to, from or within Golgi
COPI coating of Golgi vesicle
COPII vesicle coating
protein oligomerization
regulation of beta-amyloid formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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