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Invitrogen
TRBP Polyclonal Antibody
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Product Details
PA5-84053
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TARBP2. Recombinant protein control fragment (Product #RP-101324).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TVGDTSCTGQ GPSKKAAKHK AAEVALKHLK GGSMLEPALE DSSSFSPLDS SLPEDIPVFT AAAAAT
Highest antigen sequence indentity to the following orthologs: Mouse - 89%, Rat - 88%.
Target Information
TRBP belongs to the family of dsRNA-binding proteins. It consists of highly conserved 2 dsRNA-binding domains and C-terminal basic region. It is a unique cellular protein capable of binding to HIV-TAR RNA and stimulates expression of HIV-1 long terminal repeats. It also inhibits the host antiviral and anti-proliferative mechanisms by directly binding to IFN-regulated dsRNA-dependent protein kinase (PKR). TRBP associates with Ago2 protein and forms an integral component of Dicer-containing complex. It has a role in micro RNA processing and in RISC assembly. Other functions of TRBP include promoting cellular growth and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RISC-loading complex subunit TARBP2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; TAR (HIV-1) RNA binding protein 2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TARBP2, RISC loading complex RNA binding subunit; trans-activation responsive RNA-binding protein; Trans-activation-responsive RNA-binding protein; unnamed protein product
Gene Aliases: LOQS; TARBP2; TRBP; TRBP1; TRBP2
UniProt ID: (Human) Q15633
Entrez Gene ID: (Human) 6895
cytoplasmic pattern recognition receptor signaling pathway
regulation of translation
negative regulation of protein kinase activity
spermatid development
single fertilization
posttranscriptional regulation of gene expression
production of siRNA involved in RNA interference
gene silencing by RNA
pre-miRNA processing
production of miRNAs involved in gene silencing by miRNA
multicellular organism growth
negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
skeletal muscle tissue regeneration
positive regulation of viral genome replication
positive regulation of translation
regulation of viral transcription
negative regulation of defense response to virus by host
positive regulation of muscle cell differentiation
regulation of protein metabolic process
neural precursor cell proliferation
protein K63-linked ubiquitination
regulation of production of small RNA involved in gene silencing by RNA
regulation of production of siRNA involved in chromatin silencing by small RNA
small RNA loading onto RISC
global gene silencing by mRNA cleavage
regulation of production of miRNAs involved in gene silencing by miRNA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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