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Invitrogen
ST2 Polyclonal Antibody
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FIGURE: 1 / 1
ST2 Antibody (PA5-114780) in WB
Western blot analysis of ST2 in extracts from various samples. Samples were incubated with ST2 polyclonal antibody (Product # PA5-114780). Lane 1: Mouse brain, blocked with antigen-specific peptides; Lane 2: Mouse brain; Lane 3: Hepg2 cells (heat-shock treatment); Lane 4: Hela cells (heat-shock treatment).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-114780
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IL1RL1(Accession Q01638), corresponding to amino acid residues A365-Y415.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ST2.
Target Information
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL-1RL1; IL-33R; interleukin 1 receptor-related protein; interleukin-33 receptor alpha chain; Interleukin1 receptor like 1; lymphocyte antigen 84; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; soluble protein receptor; suppressor of tumorigenicity 2; T1 protein precursor; unnamed protein product
Gene Aliases: DER4; FIT-1; IL33R; Ly84; ST2; St2-rs1; ST2L; ST2V; T1; T1/ST2
UniProt ID: (Human) Q01638, (Mouse) P14719
Entrez Gene ID: (Human) 9173, (Mouse) 17082
negative regulation of T-helper 1 type immune response
inflammatory response
immune response
signal transduction
macrophage differentiation
negative regulation of interferon-gamma production
positive regulation of chemokine production
positive regulation of interleukin-5 production
interleukin-33-mediated signaling pathway
positive regulation of macrophage activation
positive regulation of inflammatory response
positive regulation of immune system process
negative regulation of cell proliferation
response to wounding
negative regulation of I-kappaB kinase/NF-kappaB signaling
regulation of inflammatory response
cellular response to cytokine stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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