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Invitrogen
TMP21 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-20315
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide from near the carboxy terminus of human TMP21.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Raji cell lysate.
PA5-20315 can be used with blocking peptide PEP-0435.
Target Information
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); ORF; putative; p24 family protein delta-1; p24delta; p24delta1; testicular tissue protein Li 206; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21; unnamed protein product
Gene Aliases: 1110014C03Rik; p23; P24(DELTA); p24d1; p24delta1; S31I125; S31III125; Tmp-21-I; TMP21
UniProt ID: (Human) P49755, (Rat) Q63584, (Mouse) Q9D1D4
Entrez Gene ID: (Human) 10972, (Rat) 84599, (Mouse) 68581
kidney development
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
vesicle-mediated transport
positive regulation of interleukin-1 production
COPI-coated vesicle budding
response to alkaloid
regulated exocytosis
Golgi vesicle transport
positive regulation of protein secretion
protein transmembrane transport
protein localization to ERGIC
cytosol to ERGIC protein transport
regulation of beta-amyloid formation
cargo loading into vesicle
COPI coating of Golgi vesicle
COPII vesicle coating
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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