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Invitrogen
Human CCDC37 (aa 49-135) Control Fragment Recombinant Protein
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Product Details
RP-100196
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
PSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (62%), Rat (62%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-61223. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
CCDC37 (Coiled-Coil Domain-Containing 37) is a gene that encodes a protein involved in various cellular functions, including cytoskeletal organization, cell motility, and signal transduction. The gene is located on chromosome 9 and plays a crucial role in maintaining cell structure and function. Research has shown that CCDC37 is epigenetically repressed in certain cancers, such as lung tumors associated with chronic obstructive pulmonary disease (COPD). Methylation of the CCDC37 promoter is more prevalent in tumors from COPD patients, suggesting its role in tumor progression and possibly serving as a biomarker for cancer diagnosis and prognosis. Additionally, CCDC37 has been implicated in the regulation of ciliary function, further highlighting its importance in cellular processes. The protein's involvement in both cancer biology and ciliary dynamics underscores its multifaceted roles in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cilia- and flagella-associated protein 100; coiled-coil domain containing 37; Coiled-coil domain-containing protein 37; unnamed protein product
Gene Aliases: CCDC37; CFAP100; MIA1
UniProt ID: (Human) Q494V2
Entrez Gene ID: (Human) 348807
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