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Invitrogen
CCDC37 Polyclonal Antibody
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Product Details
PA5-61223
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC37. Recombinant protein control fragment (Product #RP-100196).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSANPFHLSG DVDFFLLRDQ ERNKALSERQ QQKTMRVHQK MTYSSKVSAK HTSLRRQLQL EDKQEDLEAR AEAEHQRAFR DYTTWKL
Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 67%.
Target Information
CCDC37 (Coiled-Coil Domain-Containing 37) is a gene that encodes a protein involved in various cellular functions, including cytoskeletal organization, cell motility, and signal transduction. The gene is located on chromosome 9 and plays a crucial role in maintaining cell structure and function. Research has shown that CCDC37 is epigenetically repressed in certain cancers, such as lung tumors associated with chronic obstructive pulmonary disease (COPD). Methylation of the CCDC37 promoter is more prevalent in tumors from COPD patients, suggesting its role in tumor progression and possibly serving as a biomarker for cancer diagnosis and prognosis. Additionally, CCDC37 has been implicated in the regulation of ciliary function, further highlighting its importance in cellular processes. The protein's involvement in both cancer biology and ciliary dynamics underscores its multifaceted roles in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cilia- and flagella-associated protein 100; coiled-coil domain containing 37; Coiled-coil domain-containing protein 37; unnamed protein product
Gene Aliases: CCDC37; CFAP100; MIA1
UniProt ID: (Human) Q494V2
Entrez Gene ID: (Human) 348807
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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