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Invitrogen
Human C19orf48 Control Fragment Recombinant Protein
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Product Details
RP-99147
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
MTVLEAVLEIQAITGSRLLSMVPGPARPPGSCWDPTQCTRTWLLSHTPRRRWISGLPR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (40%), Rat (40%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-59814. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The C19orf48 gene, located on chromosome 19q13, encodes a protein involved in various biological processes, including its role as a minor histocompatibility antigen recognized by CD8+ T cells. This gene has been implicated in oncogenesis due to its elevated expression in certain cancer types, such as breast cancer, where it has been associated with poor prognosis. The non-synonymous single-nucleotide polymorphisms within C19orf48 contribute to differential T-cell recognition in donor and recipient cells, highlighting its significance in immune responses. Additionally, C19orf48 has been linked with SNORD88C, a small nucleolar RNA (snoRNA) that guides methylation of rRNA, further illustrating its involvement in cellular proliferation and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: multidrug resistance-related protein
Entrez Gene ID: (Human) 84798
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