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Thermo Scientific Chemicals

5-Bromo-2'-Desoxyuridin, 99 %, Thermo Scientific Chemicals

Katalognummer: H27260.06
5 g, Each
5-Bromo-2'-Desoxyuridin, 99 %, Thermo Scientific Chemicals
5-Bromo-2'-Desoxyuridin, 99 %, Thermo Scientific Chemicals
5-Bromo-2'-Desoxyuridin, 99 %, Thermo Scientific Chemicals
Zertifikate
Thermo Scientific Chemicals

5-Bromo-2'-Desoxyuridin, 99 %, Thermo Scientific Chemicals

Katalognummer: H27260.06
5 g, Each
Menge
Zertifikate
Katalognummer: H27260.06
auch als H27260-06 bezeichnet
Preis (EUR)
Preis 351,00
Online-Preis: 315,90
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Chemikalien-Kennzeichnungen

CAS
59-14-3
IUPAC Name
5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
Molecular Formula
C9H11BrN2O5
InChI Key
WOVKYSAHUYNSMH-RRKCRQDMSA-N
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(Br)C(=O)NC1=O

Spezifikationen

DatenblattDatenblatt
Appearance (Color)
White to pale cream
Assay (HPLC)
≥98.5%
Optical Rotation
+31.0 ± 1.5? (c=1 in 0.1N NaOH) or +23.0 ± 1? (c=1 in water)
Form
Crystals or powder or crystalline powder
Identification (FTIR)
Conforms (UK sourced product only)

Beschreibung

5-Bromo-2'-deoxyuridine (BrdU) is a thymidine analog used to label DNA. It is incorporated into newly synthesized DNA in place of thymidine during the S phase of the cell cycle. Cells that were actively proliferating can then be detected by denaturing the DNA and allowing specific antibodies to target the BrdU incorporation. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Anwendungen
5-Brom-2′-Desoxyuridin (BrdU) ist ein Thymidin-Analogon zur Kennzeichnung von DNA. Es wird in der S-Phase des Zellzyklus anstelle von Thymidin in neu synthetisierte DNA integriert. Zellen, die sich aktiv proliferieren, können dann durch Denaturieren der DNA und Einbinden spezifischer BrdU-Antikörper nachgewiesen werden. Folglich wird 5-BrdU zur Untersuchung der Zellsignalisierung und anderer Prozesse verwendet, die die Zellproliferation induzieren.

Löslichkeit
Wasserlöslich.

Hinweise
Kühl lagern. Behälter an einem trockenen und gut belüfteten Ort dicht verschlossen halten. Von starken Oxidationsmitteln fernhalten.
RUO – Research Use Only

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    Sicherheit und Handhabung


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Skin Corrosion/Irritation
    Category 2
    Serious Eye Damage/Eye Irritation
    Category 2
    Germ Cell Mutagenicity
    Category 2
    Specific target organ toxicity - (single exposure)
    Category 3
    Label Elements
    Signal Word

    Warning

    Hazard Statements

    H315 - Causes skin irritation

    H319 - Causes serious eye irritation

    H335 - May cause respiratory irritation

    H341 - Suspected of causing genetic defects

    Precautionary Statements

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P302 + P352 - IF ON SKIN: Wash with plenty of soap and water

    P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P312 - Call a POISON CENTER or doctor if you feel unwell