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Thermo Scientific Chemicals

Bafilomycin A1, Thermo Scientific Chemicals

Katalognummer: J61835.MCR
Each
Bafilomycin A1, Thermo Scientific Chemicals
Bafilomycin A1, Thermo Scientific Chemicals
Bafilomycin A1, Thermo Scientific Chemicals
Zertifikate
Thermo Scientific Chemicals

Bafilomycin A1, Thermo Scientific Chemicals

Katalognummer: J61835.MCR
Each
Zertifikate
Informational:Informatorisch:Für diese Chemikalie benötigen wir möglicherweise zusätzliche Informationen für unsere Unterlagen zur behördlichen und chemischen Konformität. Falls erforderlich, setzen wir uns mit Ihnen in Verbindung, sobald Ihre Bestellung eingegangen ist, um diese Informationen zu erfragen.
Katalognummer: J61835.MCR
auch als J61835-M^ bezeichnet
Preis (EUR)
Preis 383,00
Online-Preis: 344,70
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Chemikalien-Kennzeichnungen

CAS
88899-55-2
IUPAC Name
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular Formula
C35H58O9
InChI Key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILES
CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

Spezifikationen

DatenblattDatenblatt
Appearance (Color)
White
Assay (HPLC)
95.0% min.
Form
Solid or film

Beschreibung

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
• It is a macrolide antibiotic, and shows fungicide activity
Application
• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
• It can be immunosuppressive
• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

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    Sicherheit und Handhabung


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Skin Corrosion/Irritation
    Category 2
    Serious Eye Damage/Eye Irritation
    Category 2
    Specific target organ toxicity - (single exposure)
    Category 3
    Label Elements
    Signal Word

    Warning

    Hazard Statements

    H315 - Causes skin irritation

    H319 - Causes serious eye irritation

    H335 - May cause respiratory irritation

    Precautionary Statements

    P261 - Avoid breathing dust/fume/gas/mist/vapors/spray

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P302 + P352 - IF ON SKIN: Wash with plenty of soap and water

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing