Thermo Scientific Chemicals

Geldanamycin, 98+%, Thermo Scientific Chemicals

Katalognummer: J63397.MB
25 mg, Each
Thermo Scientific Chemicals

Geldanamycin, 98+%, Thermo Scientific Chemicals

Katalognummer: J63397.MB
25 mg, Each
Menge
Informational:Informatorisch:Für diese Chemikalie benötigen wir möglicherweise zusätzliche Informationen für unsere Unterlagen zur behördlichen und chemischen Konformität. Falls erforderlich, setzen wir uns mit Ihnen in Verbindung, sobald Ihre Bestellung eingegangen ist, um diese Informationen zu erfragen.
Katalognummer: J63397.MB
auch als J63397-MB bezeichnet
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Menge
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Chemikalien-Kennzeichnungen

CAS
30562-34-6
IUPAC Name
13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Molecular Formula
C29H40N2O9
InChI Key
QTQAWLPCGQOSGP-UHFFFAOYNA-N
SMILES
COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O
Assay from Supplier's CofA
>98.0% (HPLC)
Form
Powder or crystals or crystalline powder
Appearance (Color)
Yellow

Beschreibung

Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins. It interferes with conformational maturation of proteins and the cellular stress response. In addition, it is a potent inhibitor of the nuclear hormone receptor family.

Solubility
Soluble in dimethyl sulfoxide at 100 mg/mL.

Notes
Store in a cool dry place. Keep away from oxidizing agents. Protect from heat.
RUO – Research Use Only

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