Search
Proteintech
CLSTN1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
12788-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLSTN1 Fusion Protein Ag3504 (29-350 aa encoded by BC033902)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ARVNKHKPW LEPTYHGIVT ENDNTVLLDP PLIALDKDAP LRFAGEICGF KIHGQNVPFD AVVVDKSTGE GVIRSKEKLD CELQKDYSFT IQAYDCGKGP DGTNVKKSHK ATVHIQVNDV NEYAPVFKEK SYKATVIEGK QYDSILRVEA VDADCSPQFS QICSYEIITP DVPFTVDKDG YIKNTEKLNY GKEHQYKLTV TAYDCGKKRA TEDVLVKISI KPTCTPGWQG WNNRIEYEPG TGALAVFPNI HLETCDEPVA SVQATVELET SHIGKGCDRD TYSEKSLHRL CGAAAGTAEL LPSPSGSLNW TMGLPTDNGH DSD (29-350 aa encoded by BC033902)
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alc-alpha; alcadein alpha; Alcadein-alpha; Alzheimer-related cadherin-like protein; cadherin-related family member 12; Calsyntenin-1; FLJ32258; Non-classical cadherin XB31alpha; unnamed protein product; X11-like binding protein 31 type alpha1
Gene Aliases: 1810034E21Rik; ALC-ALPHA; alcalpha1; alcalpha2; CDHR12; CLSTN1; CS1; CST-1; CSTN1; KIAA0911; PIK3CD; XB31alpha
UniProt ID: (Human) O94985, (Rat) Q6Q0N0, (Mouse) Q9EPL2
Entrez Gene ID: (Human) 22883, (Rat) 313717, (Mouse) 65945
regulation of cell growth
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of synaptic transmission
positive regulation of synapse assembly
regulation of synapse maturation
neurotransmitter receptor transport to postsynaptic membrane
vesicle-mediated transport in synapse
cellular calcium ion homeostasis
chemical synaptic transmission
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support