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Proteintech
RAB11A/B Polyclonal Antibody
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Product Details
15903-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Dog,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RAB11A/B Fusion Protein Ag8742 (1-216 aa encoded by BC013348)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize both RAB11A (24 kDa) and RAB11B(24 kDa).
Immunogen sequence: MGTRDDEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFNLE SKSTIGVEFA TRSIQVDGKT IKAQIWDTAG QERYRAITSA YYRGAVGALL VYDIAKHLTY ENVERWLKEL RDHADSNIVI MLVGNKSDLR HLRAVPTDEA RAFAEKNGLS FIETSALDST NVEAAFQTIL TEIYRIVSQK QMSDRRENDM SPSNNVVPIH VPPTTENKPK VQCCQNI (1-216 aa encoded by BC013348)
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GTP-binding protein YPT3; GTPase; RAB 11A, member oncogene family; Rab-11; RAB11A; RAB11B; RAB11B, member of RAS oncogene family; RAS oncogene family protein; Ras-related protein Rab-11A; Ras-related protein Rab-11B; unnamed protein product; YL8; YPT3
Gene Aliases: A730055L17Rik; H-YPT3; NDAGSCW; RAB11; RAB11A; RAB11B; YL8; YPT3
UniProt ID: (Human) P62491, (Human) Q15907, (Mouse) P62492, (Mouse) P46638
Entrez Gene ID: (Human) 8766, (Human) 9230, (Mouse) 53869, (Mouse) 19326
cytokinesis
transport
intracellular protein transport
exocytosis
cell cycle
mitotic metaphase plate congression
small GTPase mediated signal transduction
metabolic process
positive regulation of epithelial cell migration
regulation of multivesicular body size
positive regulation of G2/M transition of mitotic cell cycle
protein transport
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
Rab protein signal transduction
multivesicular body assembly
positive regulation of axon extension
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
exosomal secretion
mitotic cytokinesis
vesicle docking involved in exocytosis
microtubule-based movement
regulation of cytokinesis
protein localization to cell surface
Golgi to plasma membrane protein transport
positive regulation of cilium assembly
plasma membrane to endosome transport
early endosome to recycling endosome transport
protein localization to cilium
protein transmembrane transport
vesicle-mediated transport to the plasma membrane
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
synaptic vesicle endosomal processing
amyloid-beta clearance by transcytosis
regulation of cilium assembly
regulation of early endosome to recycling endosome transport
positive regulation of protein localization to plasma membrane
positive regulation of mitotic cytokinetic process
regulation of protein localization to centrosome
protein localization to cleavage furrow
regulation of endocytic recycling
receptor recycling
endocytic recycling
transferrin transport
insulin secretion involved in cellular response to glucose stimulus
regulation of anion transport
constitutive secretory pathway
regulated exocytosis
cellular response to acidic pH
regulation of protein localization to cell surface
endocytosis
retrograde transport, endosome to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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