RAB11A/RAB11B Antibodies

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

Synonyms

A730055L17Rik; GTP-binding protein YPT3; H-YPT3; RAB 11A, member oncogene family; RAB11; rab-11; RAB11A; RAB11A, member RAS oncogene family; RAB11B; RAB11B, member of RAS oncogene family; RAB11B, member RAS oncogene family; RAS oncogene family protein; ras-related protein Rab-11A; Ras-related protein Rab-11B; YL8; YPT3