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Proteintech

PTPN11 Polyclonal Antibody

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View all (64) SHP2 antibodies

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PTPN11 Polyclonal Antibody

Product Details

24570-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PTPN11 Fusion Protein Ag21472 (1-460 aa encoded by BC008692)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Amount

45 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTSRRWFHP NITGVEAENL LLTRGVDGSF LARPSKSNPG DFTLSVRRNG AVTHIKIQNT GDYYDLYGGE KFATLAELVQ YYMEHHGQLK EKNGDVIELK YPLNCADPTS ERWFHGHLSG KEAEKLLTEK GKHGSFLVRE SQSHPGDFVL SVRTGDDKGE SNDGKSKVTH VMIRCQELKY DVGGGERFDS LTDLVEHYKK NPMVETLGTV LQLKQPLNTT RINAAEIESR VRELSKLAET TDKVKQGFWE EFETLQQQEC KLLYSRKEGQ RQENKNKNRY KNILPFDHTR VVLHDGDPNE PVSDYINANI IMPEFETKCN NSKPKKSYIA TQGCLQNTVN DFWRMVFQEN SRVIVMTTKE VERGKSKCVK YWPDEYALKE YGVMRVRNVK ESAAHDYTLR ELKLSKVGQG NTERTVWQYH FRTWPDHGVP SDPGGVLDFL EEVHHKQESI MDAGPVVVHC R (1-460 aa encoded by BC008692)

Target Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2SH2 domain protein; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP-1D; PTP-2C; PTP1C; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase 2; SHP-2; Tyrosine-protein phosphatase non-receptor type 11; unnamed protein product

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Gene Aliases: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP2; SHPTP2

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UniProt ID: (Human) Q06124

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Entrez Gene ID: (Human) 5781

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Function(s)
phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding hydrolase activity protein kinase binding receptor signaling complex scaffold activity receptor tyrosine kinase binding cadherin binding cell adhesion molecule binding peptide hormone receptor binding binding, bridging protein tyrosine kinase binding
Process(es)
DNA damage checkpoint neutrophil activation involved in immune response lipid metabolic process triglyceride metabolic process signal transduction epidermal growth factor receptor signaling pathway integrin-mediated signaling pathway axonogenesis brain development heart development fibroblast growth factor receptor signaling pathway hormone-mediated signaling pathway positive regulation of signal transduction cytokine-mediated signaling pathway cerebellar cortex formation platelet formation T cell costimulation positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of chondrocyte differentiation negative regulation of type I interferon production positive regulation of type I interferon production microvillus organization positive regulation of interferon-beta production positive regulation of tumor necrosis factor production regulation of cell adhesion mediated by integrin negative regulation of cell adhesion mediated by integrin multicellular organism growth organ growth peptidyl-tyrosine dephosphorylation megakaryocyte development atrioventricular canal development ERBB signaling pathway negative regulation of T cell proliferation vasodilation hormone metabolic process glucose homeostasis regulation of protein complex assembly regulation of MAPK cascade positive regulation of ossification positive regulation of mitotic cell cycle positive regulation of glucose import positive regulation of insulin receptor signaling pathway negative regulation of insulin secretion regulation of protein export from nucleus positive regulation of hormone secretion negative regulation of hormone secretion platelet-derived growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway genitalia development inner ear development homeostasis of number of cells within a tissue negative regulation of cortisol secretion positive regulation of protein kinase B signaling Bergmann glial cell differentiation negative regulation of growth hormone secretion face morphogenesis regulation of type I interferon-mediated signaling pathway intestinal epithelial cell migration positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to epidermal growth factor stimulus positive regulation of intracellular signal transduction negative regulation of neutrophil activation
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