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Bethyl Laboratories
Exonuclease 1 Polyclonal Antibody
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FIGURE: 1 / 1
Exonuclease 1 Antibody (A302-640A) in WB
Detection of human Exonuclease 1 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-Exonuclease 1 antibody (Product # A302-640A) used for WB at 0.04 µg/mL (A) and 0.4 µg/mL (B) and used for IP at 10 µg/mg lysate. Exonuclease 1 was also immunoprecipitated by rabbit anti-Exonuclease 1 antibody A302-639A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times... View More
Product Details
A302-640A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 796 and 846 of human exonuclease 1.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExo1p; hExoI; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1; unnamed protein product
Gene Aliases: EXO1; EXOI; HEX1; hExoI
UniProt ID: (Human) Q9UQ84
Entrez Gene ID: (Human) 9156
DNA binding
chromatin binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
RNA-DNA hybrid ribonuclease activity
exonuclease activity
protein binding
5'-3' exonuclease activity
hydrolase activity
hydrolase activity, acting on ester bonds
5'-flap endonuclease activity
5'-3' exodeoxyribonuclease activity
single-stranded DNA 5'-3' exodeoxyribonuclease activity
metal ion binding
flap endonuclease activity
double-stranded DNA 5'-3' exodeoxyribonuclease activity
immune system process
humoral immune response mediated by circulating immunoglobulin
DNA repair
mismatch repair
DNA recombination
cellular response to DNA damage stimulus
somatic hypermutation of immunoglobulin genes
isotype switching
meiotic cell cycle
t-circle formation
DNA strand resection involved in replication fork processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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