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          • Primary Antibodies ›
          • MECP2 Antibodies

          Proteintech

          MECP2 Polyclonal Antibody, CoraLite® Plus 488

          View all (43) MECP2 antibodies

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          Cite MECP2 Polyclonal Antibody, CoraLite® Plus 488

          Additional Information:
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          • Antibody Testing Data (2)
          MECP2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          MECP2 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          MECP2 Antibody (CL48810861100UL) in ICC/IF

          Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CoraLite 488 MECP2 antibody (Product # CL48810861100UL)) at dilution of 1:100, CL594-Phalloidin (red). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MECP2 Antibody in Immunocytochemistry (ICC/IF)
          MECP2 Antibody in Flow Cytometry (Flow)
          MECP2 Polyclonal Antibody, CoraLite® Plus 488

          Product Details

          CL48810861100UL

          Applications
          Tested Dilution
          Publications

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          -

          Flow Cytometry (Flow)

          0.2 µg
          -
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Conjugate

          CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

          Excitation/Emission Max

          493/522 nm

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 0.5% BSA, 50% glycerol

          Contains

          0.05% ProClin 300

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles, store in dark

          Shipping conditions

          Wet ice

          Target Information

          MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: DKFZp686A24160; MeCp-2 protein; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Methyl-CpG-binding protein 2; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product

          View more View less

          Gene Aliases: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10

          View more View less

          UniProt ID: (Human) P51608, (Mouse) Q9Z2D6

          View more View less

          Entrez Gene ID: (Human) 4204, (Mouse) 17257

          View more View less

          Function(s)
          nucleic acid binding DNA binding chromatin binding transcription corepressor activity RNA binding mRNA binding protein binding methyl-CpG binding double-stranded methylated DNA binding siRNA binding binding, bridging histone reader activity molecular condensate scaffold activity promoter-specific chromatin binding four-way junction DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding poly(A) RNA binding unmethylated CpG binding protein N-terminus binding DNA metabolism protein
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process regulation of transcription from RNA polymerase II promoter glutamine metabolic process cellular biogenic amine metabolic process Notch signaling pathway chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization glucocorticoid metabolic process cell proliferation associative learning adult locomotory behavior visual learning post-embryonic development gene expression regulation of gene expression negative regulation of gene expression glial cell proliferation dendrite development negative regulation of angiogenesis proprioception sensory perception of pain cerebellum development ventricular system development neuron differentiation neuron projection development heterochromatin assembly cardiolipin metabolic process multicellular organismal response to stress social behavior regulation of gene expression, epigenetic neuron maturation negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration hypermethylation of CpG island negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylcholine metabolic process regulation of synaptic plasticity cell development catecholamine secretion neuromuscular process controlling posture neuromuscular process negative regulation of developmental process negative regulation of smooth muscle cell differentiation response to other organism excitatory postsynaptic potential positive regulation of glial cell proliferation long-term synaptic potentiation genetic imprinting positive regulation of microtubule nucleation trans-synaptic signaling by BDNF regulation of multicellular organismal development mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of cell proliferation pathogenesis embryo development histone methylation histone acetylation negative regulation of histone methylation negative regulation of histone acetylation regulation of DNA methylation negative regulation of astrocyte differentiation positive regulation of synapse assembly
          It has to be done as per old AB suggested Products section.

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