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Bethyl Laboratories
Phospho-MCM2 (Ser41) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-MCM2 (Ser41) Antibody (IHC-00015) in IHC (P)
Detection of human phospho-MCM2 (Ser 41) by immunohistochemistry. Sample: FFPE section of human colon adenocarcinoma. Antibody: Affinity purified rabbit anti-Phospho-MCM2 (Ser 41) (Product # IHC-00015) used at a dilution of 1:100. Detection: DAB.
Product Details
IHC-00015
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphorylated peptide, which represented a portion of Human Minichromosomal Maintenance Deficient 2 surrounding Serine 41.
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis, X. tropicalis, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey and Gorilla
Target Information
MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. MCM2 has been mapped to 3q21. From its localization, CDCL1 became a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell devision cycle-like 1; cyclin-like 1; DNA replication licensing factor MCM2; KIAA0030; MGC10606; mini chromosome maintenance deficient 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; Nuclear protein BM28; unnamed protein product
Gene Aliases: AA959861; AW476101; BM28; CCNL1; cdc19; CDCL1; D3S3194; DFNA70; KIAA0030; MCM2; Mcmd2; MITOTIN; mKIAA0030
UniProt ID: (Human) P49736, (Mouse) P97310
Entrez Gene ID: (Human) 4171, (Mouse) 17216
nucleotide binding
DNA binding
DNA helicase activity
DNA replication origin binding
single-stranded DNA binding
helicase activity
protein binding
ATP binding
zinc ion binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
histone binding
3'-5' DNA helicase activity
metal ion binding
DNA metabolism protein
double-strand break repair via break-induced replication
DNA replication
DNA replication initiation
nucleosome assembly
apoptotic process
regulation of DNA-dependent DNA replication initiation
cellular response to interleukin-4
cochlea development
mitotic DNA replication initiation
DNA unwinding involved in DNA replication
cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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