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Invitrogen
MAP2 Monoclonal Antibody (MT-07)
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FIGURE: 1 / 3
MAP2 Antibody (MA1-19425) in IHC (P)
Immunohistochemical analysis of MAP2 was performed using formalin-fixed paraffin-embedded human brain- frontal cortex tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 1... View More
Product Details
MA1-19425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
MT-07
Immunogen
Microtubule protein (bovine brain) enriched for kinesin
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody recognizes an epitope (aa 1375-1395) located in central domain of molecule Microtubule Associated Protein 2ab (MAP2ab), an intracellular antigen.
Target Information
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC091465.1; DKFZp686I2148; MAP 2; MAP-2; map-2a; map2ab; microtubule associated protein 2; Microtubule-associated protein 2; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
Gene Aliases: G1-397-34; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; Mtap-2; Mtap2; repro4
UniProt ID: (Human) P11137, (Mouse) P20357
Entrez Gene ID: (Pig) 100153306, (Human) 4133, (Mouse) 17756
microtubule bundle formation
axonogenesis
dendrite development
cellular response to organic substance
microtubule cytoskeleton organization
central nervous system neuron development
negative regulation of axon extension
regulation of microtubule polymerization
negative regulation of microtubule polymerization
neuron projection development
regulation of protein localization
dendrite morphogenesis
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
positive regulation of anterograde synaptic vesicle transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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