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Invitrogen

CXCL12 Monoclonal Antibody (79018), FITC

1 Published Figure
2 References
View all (27) CXCL12 antibodies

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CXCL12 Monoclonal Antibody (79018), FITC

Product Details

MA5-23547

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-Dependent
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

79018

Immunogen

E. coli-derived recombinant human CXCL12/SDF-1 alpha Lys22-Lys89
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Purification

Protein A/G

Storage buffer

Buffered saline solution with ≤ 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2608710

Target Information

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 12; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) ligand 12; CXC; CXC motif chemokine; CXCL; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1; SDF-1 delta; chemokine (C-X-C motif) ligand 12 transcript variant 5; SDF-1 epsilon; chemokine (C-X-C motif) ligand 12 transcript variant 6; SDF-1 gamma; chemokine (C-X-C motif) ligand 12 transcript variant 4; SDF-1 theta; chemokine (C-X-C motif) ligand 12 transcript variant 7; SDF-1a; SDF-1b; SDF1a; Stromal cell-derived factor 1; stromal cell-derived factor-1 alpha; Thymic lymphoma cell-stimulating factor; TLSF; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1; unnamed protein product

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Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1

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UniProt ID: (Human) P48061, (Mouse) P40224

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Entrez Gene ID: (Human) 6387, (Mouse) 20315

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Function(s)
receptor binding cytokine activity integrin binding protein binding chemokine activity growth factor activity chemokine receptor binding CXCR chemokine receptor binding
Process(es)
patterning of blood vessels ameboidal-type cell migration neuron migration positive regulation of endothelial cell proliferation chemotaxis immune response germ cell development brain development motor neuron axon guidance positive regulation of cell proliferation adult locomotory behavior germ cell migration telencephalon cell migration regulation of cell migration positive regulation of cell migration organ regeneration positive regulation of dopamine secretion T cell proliferation positive regulation of neuron differentiation positive regulation of cell adhesion positive regulation of axon extension involved in axon guidance induction of positive chemotaxis regulation of calcium ion transport cell chemotaxis chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of myoblast fusion negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of leukocyte tethering or rolling negative regulation of leukocyte apoptotic process positive regulation of T cell migration response to hypoxia cellular calcium ion homeostasis defense response cell adhesion signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway axon guidance blood circulation regulation of actin polymerization or depolymerization response to mechanical stimulus response to virus T cell chemotaxis killing of cells of other organism integrin activation chemokine (C-X-C motif) ligand 12 signaling pathway CXCL12-activated CXCR4 signaling pathway response to peptide hormone positive regulation of chemotaxis detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of calcium ion import positive regulation of vasculature development response to ultrasound cellular response to chemokine negative regulation of dendritic cell apoptotic process
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