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Invitrogen
CXCL12 Monoclonal Antibody (79018)
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FIGURE: 1 / 9
CXCL12 Antibody (MA5-23759) in ICC/IF
Immunocytochemistry analysis of CXCL12 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining). The cells were labeled with CXCL12 Mouse Monoclonal Antibody (Product # MA5-23759) using a dilution of 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red) counterstained with DAPI (blue). Specific staining was localized to cell membranes.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-23759
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
79018
Immunogen
E. coli-derived recombinant human CXCL12/SDF-1 alpha Lys22-Lys89
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine; chemokine (C-X-C motif) ligand 12; CXC; CXC motif chemokine; CXCL; CXCL12; hIRH; hSDF-1; intercrine reduced in hepatomas; interleukin-8 homolog; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; SDF-1 delta; chemokine (C-X-C motif) ligand 12 transcript variant 5; SDF-1 epsilon; chemokine (C-X-C motif) ligand 12 transcript variant 6; SDF-1 gamma; chemokine (C-X-C motif) ligand 12 transcript variant 4; SDF-1 theta; chemokine (C-X-C motif) ligand 12 transcript variant 7; SDF-1a; SDF-1b; SDF1a; stromal cell-derived factor-1 alpha; thymic lymphoma cell-stimulating factor; TLSF-a; TLSF-b; Tlsfa; Tlsfb; unnamed protein product
Gene Aliases: IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1
UniProt ID: (Human) P48061, (Mouse) P40224
Entrez Gene ID: (Human) 6387, (Mouse) 20315
patterning of blood vessels
ameboidal-type cell migration
neuron migration
positive regulation of endothelial cell proliferation
chemotaxis
defense response
immune response
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
germ cell development
axon guidance
brain development
motor neuron axon guidance
positive regulation of cell proliferation
negative regulation of cell proliferation
adult locomotory behavior
germ cell migration
T cell chemotaxis
telencephalon cell migration
regulation of cell migration
positive regulation of cell migration
organ regeneration
killing of cells of other organism
positive regulation of dopamine secretion
integrin activation
chemokine (C-X-C motif) ligand 12 signaling pathway
CXCL12-activated CXCR4 signaling pathway
T cell proliferation
positive regulation of neuron differentiation
positive regulation of cell adhesion
positive regulation of axon extension involved in axon guidance
positive regulation of chemotaxis
induction of positive chemotaxis
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of protein kinase B signaling
regulation of calcium ion transport
cell chemotaxis
antimicrobial humoral immune response mediated by antimicrobial peptide
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
dopaminergic neuron differentiation
positive regulation of monocyte chemotaxis
positive regulation of calcium ion import
cell-cell adhesion
positive regulation of myoblast fusion
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of leukocyte tethering or rolling
positive regulation of vasculature development
cellular response to chemokine
positive regulation of T cell migration
negative regulation of dendritic cell apoptotic process
response to hypoxia
cellular calcium ion homeostasis
cell adhesion
signal transduction
G-protein coupled receptor signaling pathway
blood circulation
regulation of actin polymerization or depolymerization
response to mechanical stimulus
response to virus
response to peptide hormone
response to ultrasound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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