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Invitrogen
MAP2 Polyclonal Antibody
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FIGURE: 1 / 14
MAP2 Antibody (PA1-10005) in ICC/IF
Immunofluorescent analysis of MAP2 in cortical neuron-glial cell culture. The culture was prepared from an E20 rat and stained using a MAP2 polyclonal antibody (Product # PA1-10005) at a dilution of 1:10,000 as seen in red, and a MAP-tau monoclonal antibody at a dilution of 1:2,000 as seen in green, and with DAPI staining the nuclear DNA in blue. The MAP2 antibody stains dendrites and perikarya of neurons, while the antibody to MAP-tau labels neuronal perikarya, dendrites and also axonal processes. As a result perikarya and dendrites appea... View More
Product Details
PA1-10005
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Mix of recombinant human constructs of projection domain sequences, amino acids 235-1588.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-10005 was raised against recombinant constructs of the entire human projection domain, and so recognizes only the high molecular MAP2 forms, MAP2A and MAP2B.| For long term storage, store at 4°C.
Target Information
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AC091465.1; DKFZp686I2148; MAP 2; MAP-2; map-2a; map2ab; microtubule associated protein 2; Microtubule-associated protein 2; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
Gene Aliases: G1-397-34; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; MAP2R; Mtap-2; Mtap2; repro4
UniProt ID: (Human) P11137, (Mouse) P20357, (Rat) P15146
Entrez Gene ID: (Human) 4133, (Mouse) 17756, (Rat) 25595
microtubule bundle formation
axonogenesis
dendrite development
cellular response to organic substance
central nervous system neuron development
neuron projection development
response to estradiol
response to progesterone
dendrite morphogenesis
microtubule cytoskeleton organization
negative regulation of axon extension
regulation of microtubule polymerization
negative regulation of microtubule polymerization
regulation of protein localization
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
positive regulation of anterograde synaptic vesicle transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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