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Invitrogen
MAP2 Polyclonal Antibody
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FIGURE: 1 / 7
MAP2 Antibody (PA1-16751) in ICC/IF
Immunocytochemistry analysis of MAP2 in cortical neuron-glial cell culture from E20 rat. Samples were incubated in MAP2 polyclonal antibody (Product # PA1-16751) using a dilution of 1:10000. This antibody in red, and mouse mAb to MAP-tau dilution 1:2,000, in green. The blue is DAPI staining of nuclear DNA. This antibody stains dendrites and perikarya of neurons, while Tau antibody labels neuronal perikarya, dendrites and also axonal process. As a result perikarya and dendrites appears orange-yellow, since they contain both MAP2 and tau, wh... View More
Product Details
PA1-16751
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Mouse,
Rat
Published species
Chimpanzee,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Mix of recombinant human construct of projection domain sequences, amino acids 377-1505.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Purification
IgY fraction
Storage buffer
PBS
Contains
0.035% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In Western blot bands can be seen at approximately 280 kDa, representing MAP2a and MAP2b.
Bands may also be seen at approximately 70 kDa, representing MAP2c.
Target Information
MAP2 (Microtubule Associated Protein 2) exists in two high molecular weight forms (MAP2a & MAP2b) and a low molecular weight form. The expression of MAP2 is developmentally regulated and its multiple forms arise by alternative splicing of a single gene. MAP2 is involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. MAP2 is useful in studies of neuron structure in normal and malignant brain tissue as well as in degenerative diseases such as Alzheimer's Disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AC091465.1; DKFZp686I2148; MAP 2; MAP-2; map-2a; map2ab; microtubule associated protein 2; Microtubule-associated protein 2; OTTHUMP00000163916; OTTHUMP00000208143; unnamed protein product
Gene Aliases: G1-397-34; MAP-2; MAP2; MAP2A; MAP2B; MAP2C; MAP2R; Mtap-2; Mtap2; repro4
UniProt ID: (Human) P11137, (Mouse) P20357, (Rat) P15146
Entrez Gene ID: (Human) 4133, (Mouse) 17756, (Rat) 25595
microtubule bundle formation
axonogenesis
dendrite development
cellular response to organic substance
central nervous system neuron development
neuron projection development
response to estradiol
response to progesterone
dendrite morphogenesis
microtubule cytoskeleton organization
negative regulation of axon extension
regulation of microtubule polymerization
negative regulation of microtubule polymerization
regulation of protein localization
positive regulation of anterograde dense core granule transport
regulation of organelle transport along microtubule
positive regulation of anterograde synaptic vesicle transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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