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Invitrogen
TMP21 Polyclonal Antibody
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Product Details
PA1-46004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal sequence of the human TMP21/TMED10 protein (within residues 100-200).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Amount
90 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This sequence is 100% conserved withing monkey, mouse, hamster, rat, rabbit, and bovine TMP21.
Suggested positive control: human liver protein.
Target Information
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; Integral membrane protein p23; integral membrane protein Tmp21-I (p23); ORF; putative; p23; p24 family protein delta-1; p24delta; p24delta1; Protein TMED10; S31I125; S31III125; testicular tissue protein Li 206; Tmp-21-I; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; Transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21; unnamed protein product
Gene Aliases: 1110014C03Rik; p23; P24(DELTA); p24d1; p24delta1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21
UniProt ID: (Bovine) Q5E971, (Rabbit) Q28735, (Human) P49755, (Rat) Q63584, (Mouse) Q9D1D4
Entrez Gene ID: (Bovine) 529761, (Chicken) 423362, (Rabbit) 100009296, (Human) 10972, (Rat) 84599, (Mouse) 68581
retrograde vesicle-mediated transport, Golgi to ER
COPI-coated vesicle budding
regulated exocytosis
regulation of beta-amyloid formation
intracellular protein transport
ER to Golgi vesicle-mediated transport
Golgi organization
protein transport
vesicle-mediated transport
positive regulation of interleukin-1 production
cargo loading into vesicle
vesicle targeting, to, from or within Golgi
COPI coating of Golgi vesicle
COPII vesicle coating
positive regulation of protein secretion
protein transmembrane transport
protein localization to ERGIC
cytosol to ERGIC protein transport
kidney development
vesicle targeting
response to alkaloid
protein oligomerization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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