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Invitrogen
NALP1 Polyclonal Antibody
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Product Details
PA5-116672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.97 mg/mL
Amount
197 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, SH-SY5Y
Immunogen sequence: PSPLDAPQLL HFVDQYREQL IARVTSVEVV LDKLHGQVLS QEQYERVLAE NTRPSQMRKL FSLSQSWDRK CKDGLYQALK ETHPHLIMEL WEKGSKKGLL PLSS
Target Information
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1/Ced-4 family apoptosis regulator; CARD7; caspase recruitment domain protein; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; contains NACHT, LRR and PYD domains; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT, LRR and PYD domains-containing protein 1a allele 1; NACHT/LRR/pyrin domain-containing protein 1; NLR family protein 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; resistant anthrax lethal toxin; unnamed protein product
Gene Aliases: AIADK; CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; Gm14; Gm15; JRRP; KIAA0926; MSPC; NAC; NALP1; Nalp1a; NLRP1; Nlrp1a; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000, (Mouse) Q2LKU9, (Rat) D9I2F9
Entrez Gene ID: (Human) 22861, (Mouse) 195046, (Rat) 360557
nucleotide binding
double-stranded DNA binding
double-stranded RNA binding
endopeptidase activity
protein binding
ATP binding
peptidase activity
cysteine-type endopeptidase activator activity involved in apoptotic process
hydrolase activity
ATPase activity
enzyme binding
protein domain specific binding
signaling adaptor activity
pattern recognition receptor activity
cysteine-type endopeptidase activator activity
molecular condensate scaffold activity
scaffold protein binding
response to muramyl dipeptide
defense response to bacterium
positive regulation of interleukin-1 beta secretion
programmed necrotic cell death
activation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of apoptotic process
neuron apoptotic process
activation of innate immune response
pattern recognition receptor signaling pathway
immune system process
proteolysis
apoptotic process
inflammatory response
signal transduction
programmed cell death
positive regulation of interleukin-1 beta production
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
protein homooligomerization
protein maturation
defense response to virus
pyroptosis
cellular response to UV-B
intrinsic apoptotic signaling pathway
self proteolysis
antiviral innate immune response
canonical inflammasome complex assembly
positive regulation of pyroptotic inflammatory response
pyroptotic cell death
NLRP1 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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