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Invitrogen
cGAS Polyclonal Antibody
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Product Details
PA5-121188
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 401-501 of human CGAS(NP_612450.2).
Conjugate
Form
Liquid
Concentration
2.14 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: U-87MG, Mouse testis, Mouse thymus, Rat lung. The target is usually found in the following locations: Cytoplasm, cytosol.
Immunogen sequence: EEKCCRKDCL KLMKYLLEQL KERFKDKKHL DKFSSYHVKT AFFHVCTQNP QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL ENYFIPEFNL FSSNLIDKRS K
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of 2', 5' phosphodiester linkage at the GpA step and the formation of 3', 5' phosphodiester linkage at the ApG step. This produces c[G(2',5')pA(3'5')p] responses. cGAS also binds cytosolic DNA directly, leading to the activation and synthesis of cGAMP. Then, a second messenger binds to and activates TMEM173/STING thereby triggering type-I interferon production. cGAS is also involved in innate immune sensorship of infection, detection of DNA from bacteria, response to cellular stress, DNA damage, and regulation of cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2'3'-cGAMP synthase; C6orf150; C6orf150; cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP; cGAMP synthase; Cyclic GMP-AMP synthase; DANGER family member 4; h-cGAS; Mab-21 domain containing 1; Mab-21 domain-containing protein 1; MB21D1; protein MB21D1; unnamed protein product
Gene Aliases: C6orf150; CGAS; D4; h-cGAS; MB21D1
UniProt ID: (Human) Q8N884
Entrez Gene ID: (Human) 115004
nucleotide binding
DNA binding
chromatin binding
double-stranded DNA binding
protein binding
ATP binding
GTP binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
transferase activity
nucleotidyltransferase activity
nucleosome binding
protein homodimerization activity
metal ion binding
cyclic-GMP-AMP synthase activity
molecular condensate scaffold activity
poly-ADP-D-ribose modification-dependent protein binding
activation of innate immune response
pattern recognition receptor signaling pathway
positive regulation of defense response to virus by host
immune system process
regulation of immunoglobulin production
cytoplasmic pattern recognition receptor signaling pathway
DNA repair
cellular response to DNA damage stimulus
determination of adult lifespan
cAMP-mediated signaling
cGMP-mediated signaling
signal transduction involved in regulation of gene expression
regulation of type I interferon production
positive regulation of type I interferon production
paracrine signaling
innate immune response
negative regulation of DNA repair
regulation of immune response
regulation of T cell activation
defense response to virus
cellular response to exogenous dsRNA
cGAS/STING signaling pathway
negative regulation of cGAS/STING signaling pathway
positive regulation of cytokine production involved in inflammatory response
negative regulation of double-strand break repair via homologous recombination
positive regulation of cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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