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Invitrogen

INSR Polyclonal Antibody

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View all (34) INSR antibodies

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Product Details

PA5-27334

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of human Insulin Receptor beta. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544810

Product Specific Information

Recommended positive controls: 293T, NIH-3T3, PC-12, rat liver.

Predicted reactivity: Mouse (95%), Rat (95%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD 220; CD220; CD220 antigen; CD220 beta; CD221; HHF 5; IGF-I receptor; Insulin receptor; insulin receptor precursor; insulin receptor preproprotein; IR; IR 1; IR beta; IR-1; IR1; unnamed protein product

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Gene Aliases: 4932439J01Rik; CD220; D630014A15Rik; HHF5; INSR; IR; IR-A; IR-B

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UniProt ID: (Human) P06213, (Mouse) P15208

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Entrez Gene ID: (Human) 3643, (Rat) 24954, (Mouse) 16337

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Function(s)
nucleotide binding beta-amyloid binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor receptor binding structural molecule activity protein binding ATP binding GTP binding kinase activity transferase activity protein domain specific binding protein kinase activator activity insulin-like growth factor I binding insulin-like growth factor II binding cargo receptor activity identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding macromolecular complex binding PTB domain binding receptor signaling protein tyrosine kinase activity protein kinase binding protein phosphatase binding lipoic acid binding protein complex binding 3-phosphoinositide-dependent protein kinase binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of transcription, DNA-templated receptor-mediated endocytosis transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled receptor signaling pathway learning memory positive regulation of cell proliferation insulin receptor signaling pathway epidermis development male gonad development organ morphogenesis regulation of gene expression positive regulation of macromolecule biosynthetic process regulation of glucose metabolic process male sex determination adrenal gland development positive regulation of cell migration exocrine pancreas development receptor internalization cellular response to insulin stimulus glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein complex disassembly positive regulation of MAPK cascade positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated regulation of embryonic development positive regulation of glucose import viral entry into host cell protein autophosphorylation animal organ development positive regulation of developmental growth system development positive regulation of cellular component organization regulation of multicellular organismal process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling positive regulation of respiratory burst cellular response to growth factor stimulus dendritic spine maintenance beta-amyloid clearance transport across blood-brain barrier neuron projection maintenance regulation of female gonad development activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation response to hormone response to glucose response to manganese ion regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression response to activity peptidyl-tyrosine phosphorylation transformation of host cell by virus signal transduction by protein phosphorylation response to nutrient levels activation of protein kinase activity activation of protein kinase B activity response to estradiol negative regulation of transporter activity response to insulin response to vitamin D response to testosterone response to tumor necrosis factor peptidyl-tyrosine autophosphorylation positive regulation of phosphorylation fat cell differentiation response to ethanol positive regulation of DNA replication protein heterotetramerization response to glucocorticoid phosphorylation intracellular signal transduction
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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