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Invitrogen
ANGPTL3 Polyclonal Antibody
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Product Details
PA5-34750
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ANGPTL3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: JC.
Predicted reactivity: Pig (81%), Bovine (81%).
IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANG-5; angiopoietin 5; Angiopoietin-5; Angiopoietin-like protein 3; Angiopoietin-related protein 3; ANGPTL3; hypolipidemia; unnamed protein product
Gene Aliases: ANG-5; ANGPT5; ANGPTL3; ANL3; FHBL2; hypl; UNQ153/PRO179
UniProt ID: (Human) Q9Y5C1, (Mouse) Q9R182
Entrez Gene ID: (Human) 27329, (Mouse) 30924
angiogenesis
glycerol metabolic process
lipid metabolic process
fatty acid metabolic process
phospholipid metabolic process
cell adhesion
cell-matrix adhesion
signal transduction
integrin-mediated signaling pathway
cholesterol metabolic process
phospholipid catabolic process
response to hormone
negative regulation of very-low-density lipoprotein particle remodeling
lipid storage
positive regulation of cell migration
cholesterol homeostasis
positive regulation of angiogenesis
artery morphogenesis
positive regulation of lipid catabolic process
lipid homeostasis
acylglycerol homeostasis
phospholipid homeostasis
triglyceride homeostasis
regulation of chylomicron remodeling
triglyceride metabolic process
negative regulation of phospholipase activity
negative regulation of catalytic activity
positive regulation of lipid metabolic process
negative regulation of lipoprotein lipase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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