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Invitrogen
MEKK4 Polyclonal Antibody
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FIGURE: 1 / 1
MEKK4 Antibody (PA5-75856) in WB
Western blot analysis of MEKK4 in Lane 1: A549 whole cell lysate, Lane 2: HEK293T whole cell lysate, Lane 3: PC12 whole cell lysate, Lane 4: SP20 whole cell lysate, Lane 5: H9C2 whole cell lysate, Lane 6: Raw264.7 whole cell lysate. Samples were incubated with MEKK4 polyclonal antibody (Product # PA5-75856) at a dilution of 1:500.
Product Details
PA5-75856
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human MEKK4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; predicted protein of HQ0412; PRKMK4; SAPK/ERK kinase 1; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; T-associated sex reversal
Gene Aliases: D17Rp17; D17Rp17e; KIAA0213; MAP3K4; MAPKKK4; Mek4b; MEKK 4; MEKK4; mKIAA0213; MTK1; PRO0412; RP17; Rp17a; Tas
UniProt ID: (Human) Q9Y6R4, (Mouse) O08648
Entrez Gene ID: (Human) 4216, (Mouse) 26407, (Rat) 308106
MAP kinase kinase kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
placenta development
response to UV-C
regulation of gene expression
male germ-line sex determination
positive regulation of telomere maintenance via telomerase
intracellular signal transduction
positive regulation of JUN kinase activity
positive regulation of telomerase activity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
positive regulation of telomere capping
activation of MAPK activity
protein phosphorylation
phosphorylation
determination of dorsal identity
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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