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Invitrogen
TMP21 Polyclonal Antibody
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FIGURE: 1 / 4
TMP21 Antibody (PA5-78350) in IHC (P)
TMP21 Polyclonal Antibody detects TMP21 protein at cytosol on rat brain stem by immunohistochemical analysis. Sample: Paraffin-embedded rat brain stem. TMP21 Polyclonal Antibody (Product # PA5-78350) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78350
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TMP21. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: 293T, HepG2, Neuro2A, CD830, NIH-3T3, Raw264.7, C2C12, PC-12, Rat-2
Predicted Reactivity: Zebrafish (95%), Rabbit (99%), Chicken (96%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); ORF; putative; p23; p24 family protein delta-1; p24delta; p24delta1; Protein TMED10; S31I125; S31III125; testicular tissue protein Li 206; Tmp-21-I; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; Transmembrane protein Tmp21; transmembrane trafficking protein; transmembrane trafficking protein 21; unnamed protein product
Gene Aliases: 1110014C03Rik; p23; P24(DELTA); p24d1; p24delta1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21
UniProt ID: (Human) P49755, (Rat) Q63584, (Mouse) Q9D1D4
Entrez Gene ID: (Human) 10972, (Rat) 84599, (Mouse) 68581
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
protein transport
vesicle-mediated transport
positive regulation of interleukin-1 production
cargo loading into vesicle
COPI-coated vesicle budding
regulated exocytosis
vesicle targeting, to, from or within Golgi
COPI coating of Golgi vesicle
COPII vesicle coating
positive regulation of protein secretion
protein transmembrane transport
protein localization to ERGIC
cytosol to ERGIC protein transport
regulation of beta-amyloid formation
kidney development
vesicle targeting
response to alkaloid
protein oligomerization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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