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PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech®
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FIGURE: 1 / 1
PeproGMP® Human Heregulin beta-1 Protein (GMP100-03-100UG) in Bioactivity
Cell proliferation assay analysis of PeproGMP® Human Heregulin beta-1 Recombinant Protein, PeproTech (Product # GMP100-03-50UG) compared to Human Heregulin beta-1, Animal-Free Recombinant Protein, PeproTech (Product # AF-100-03-1MG), demonstrating comparable bioactivity across product grades.
Product Details
GMP100-03-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Human
Expression System
E. coli
Amino acid sequence
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Molecular weight
7.5 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
≤0.1 EU/µg
Activity
Determined by proliferation of human MCF-7 cells.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient
Product Specific Information
The neuregulin/heregulin protein is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). The PeproTech Recombinant Human Heregulin beta-1 (HRG1-beta1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin beta-1 (65 amino acid residues).
Reconstitute using sterile water (i.e., WFI) to a concentration of 0.1-1.0 mg/ml.
Additional product information, specifications, handling and reconstitution information are provided on the Certificate of Analysis.
All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
Target Information
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
Bioinformatics
Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; growth factor; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1; NRG1; NRG1 class VII isoform alpha 2a; NRG1 class VII isoform alpha 2b; NRG1 class VII isoform alpha beta 2a; NRG1 class VII isoform alpha beta 3; NRG1 class VII isoform beta 2a; NRG1 class VII isoform beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; unnamed protein product
Gene Aliases: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF
UniProt ID: (Human) Q02297
Entrez Gene ID: (Human) 3084
Disclaimer
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