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Invitrogen
Human CDK13/cyclin K, GST Tag, His Tag Recombinant Protein
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Product Details
A33510
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
CDK13: 656 -1050, Cyclin K: 1-300
Tag
GST-tag, His-tag
Molecular weight
73.8-63.0 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM HEPES, pH 7.5, with 5mM DTT, 100mM NaCl, 15mM glutathione, 20% glycerol
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CDK13/cyclin K recombinant human protein (CDK13: 656-1050, cyclin K 1-300) was expressed in insect cells.
CDK13/cyclin K recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the LanthaScreen™ Eu Kinase Binding assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Recombinant, Active, Catalytic
The gene accession number for CDK13 and cyclin K are NP_003709.3 and NP_001092872.1.
Target Information
Cyclin-dependent kinase 13 (CDK13) and Cyclin K form a complex that is integral to RNA processing and transcription regulation. CDK13, a member of the CDK family, is involved in the modulation of gene expression through phosphorylation of the C-terminal domain of RNA Polymerase II, affecting the transcription elongation phase. Cyclin K acts as a regulatory partner to CDK13, stabilizing its active conformation to efficiently catalyze its kinase functions. CDK13, along with Cyclin K, plays a pivotal role in RNA metabolism, influencing RNA splicing and 3' end processing, which are crucial for the synthesis of mature mRNA. Structural studies have characterized CDK13 as having unique features differentiating it from other CDKs, including distinctive domain arrangements that enable interaction with Cyclin K. The dysregulation of CDK13/Cyclin K activity has been observed in various diseases, including cancer, pointing to their importance as therapeutic targets. Research also highlights CDK13's involvement in maintaining cellular homeostasis, underscoring the complex network of interactions this kinase engages in beyond transcriptional control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC2-related protein kinase 5; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; Cholinesterase-related cell division controller; Cyclin-dependent kinase 13; Cyclin-K; hCDK13
Gene Aliases: CCNK; CDC2L; CDC2L5; CDK13; CHED; CPR4; hCDK13; KIAA1791
UniProt ID: (Human) O75909, (Human) Q14004
Entrez Gene ID: (Human) 8812, (Human) 8621
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