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Invitrogen
Human CSNK1A1L, GST Tag Recombinant Protein
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Product Details
A33354
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
Full length
Tag
GST-tag
Molecular weight
65.4 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris HCl, pH 7.5, with 25% glycerol, 0.1mM PMSF, 0.25mM DTT, 150mM NaCl, 0.1mM EDTA, 10mM glutathione
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This CSNK1A1L recombinant human protein (full length) was expressed in insect cells.
CSNK1A1L recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service.
• Validated for use with the Z'-LYTE™ assay
• Available in multiple pack sizes for convenient use
• Also available in our SelectScreen Kinase Profiling Service
Protein Form: Full Length, Recombinant, Active
The gene accession number for CSNK1A1L is AAH28723.1.
Target Information
CSNK1A1L serine/threonine kinase or CK1-alpha dynamically associates with the CBM complex upon T cell receptor engagement to participate in cytokine production and lymphocyte proliferation which has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. It governs antigen-receptor-induced NF-kappa-B activation and human lymphoma cell survival. These kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins including CTNNB1, PER1, and PER2. CSNK1A1 also participates in Wnt signaling. It may play a role in segregating chromosomes during mitosis, as well as, cytoskeleton diassembly which may regulate epithelial cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha-like; CK1; CKI-alpha-like
Gene Aliases: CK1; CSNK1A1L
UniProt ID: (Human) Q8N752
Entrez Gene ID: (Human) 122011
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