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Product Details
RP-75692
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Amino acids Ser82-Thr190 containing an N-terminal His-tag
Tag
His-tag
Class
Recombinant
Type
Protein
Purity
>95%, by SDS-PAGE under reducing conditions
Conjugate
Form
Liquid
Concentration
0.11 mg/mL
Purification
purified
Storage buffer
0.025M sodium acetate, pH 4.8, with 50% glycerol, 1mM EDTA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
This product contains purified recombinant human PDGF B protein with an N-terminal hexahistidine tag.
This product may be used as a positive control in many immunological assays.
Target Information
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: becaplermin; PDGF subunit B; PDGF, B chain; PDGF-2; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Proto-oncogene c-Sis
Gene Aliases: c-sis; IBGC5; PDGF-2; PDGF2; PDGFB; SIS; SSV
UniProt ID: (Human) P01127
Entrez Gene ID: (Human) 5155
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