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Invitrogen
Human RNASE7 Control Fragment Recombinant Protein
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Product Details
RP-88942
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGPVSLTMCKLTSGKYPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRV
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-52184. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The RNASE7 gene encodes a ribonuclease enzyme characterized by its potent ribonucleolytic activity and antimicrobial properties. It is part of the RNase A superfamily, featuring eight conserved cysteines and a catalytic histidine-lysine-histidine triad. RNase 7 is expressed in various somatic tissues, including the liver, kidney, skeletal muscle, and heart, and is prominently found in the stratum corneum of human skin. Its role is crucial in innate immune defense, assisting in the high resistance of human skin against infections. The expression of RNASE7 can be significantly induced by pro-inflammatory cytokines such as interferon-?, interleukin 1β, and to a lesser extent by tumor necrosis factor-a. This induction highlights its role in immune responses. Beyond its antimicrobial activity, RNase 7 has been shown to play a role in translating self-nucleic acids into TLR9 activators, influencing the DNA-mediated activation of immune cells like keratinocytes. These functions underscore RNASE7's significance in both maintaining skin barrier function and modulating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ribonuclease 7; ribonuclease, RNase A family, 7; RNase 7; SAP-2; Skin-derived antimicrobial protein 2
Gene Aliases: RAE1; RNASE7; UNQ2516/PRO6006
UniProt ID: (Human) Q9H1E1
Entrez Gene ID: (Human) 84659
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