Search
Invitrogen
RNASE7 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-52184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNASE7. Recombinant protein control fragment (Product #RP-88942).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KGMTSSQWFK IQHMQPSPQA CNSAMKNINK HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS HGPVSLTMCK LTSGKYPNCR YKEKRQNKSY VVACKPPQKK DSQQFHLVPV HLDRV
Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 56%.
Target Information
The RNASE7 gene encodes a ribonuclease enzyme characterized by its potent ribonucleolytic activity and antimicrobial properties. It is part of the RNase A superfamily, featuring eight conserved cysteines and a catalytic histidine-lysine-histidine triad. RNase 7 is expressed in various somatic tissues, including the liver, kidney, skeletal muscle, and heart, and is prominently found in the stratum corneum of human skin. Its role is crucial in innate immune defense, assisting in the high resistance of human skin against infections. The expression of RNASE7 can be significantly induced by pro-inflammatory cytokines such as interferon-gamma, interleukin 1 beta, and to a lesser extent by tumor necrosis factor-a. This induction highlights its role in immune responses. Beyond its antimicrobial activity, RNase 7 has been shown to play a role in translating self-nucleic acids into TLR9 activators, influencing the DNA-mediated activation of immune cells like keratinocytes. These functions underscore RNASE7's significance in both maintaining skin barrier function and modulating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: ribonuclease, RNase A family, 7; RNase 7; SAP-2; skin-derived antimicrobial protein 2; unnamed protein product
Gene Aliases: RAE1
UniProt ID: (Human) Q9H1E1
Entrez Gene ID: (Human) 84659
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support